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The match, held before their upcoming Champions League clash with Bayern, saw Leverkusen's goals from Nathan Tella (26), Nordi Mukiele (29), Patrick Schick (33), and Alex Garcia (62). Frankfurt’s lone goal came from Ugo Ekitike (37).
With this win, Leverkusen moved to second place with 53 points, while Frankfurt remained in third with 42 points, just one ahead of Mainz in fourth.
Frankfurt’s form has been inconsistent since the departure of Egyptian striker Omar Marmoush to Manchester City.
Meanwhile, Borussia Dortmund strengthened their bid for a top-four finish with a 2-0 away win against St. Pauli. The results set up an exciting clash between Leverkusen and Bayern in the Champions League next week.