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Inter Milan took the lead in the 6th minute through Davide Frattesi, and Lautaro Martinez added the second goal in the 39th minute.
In the 57th minute, Denzel Dumfries scored the third goal for Inter Milan, while Mehdi Taremi completed Inter's quartet in the 61st minute from a penalty kick.
Inter Milan raised their tally to 50 points in second place, three points behind the leader Napoli.
On the other hand, Lecce's tally froze at 20 points in seventeenth place.