Loading...
Goals from Romelu Lukaku, Youri Tielemans and Jeremy Doku inside half an hour had given Belgium a dream start.
Wales, though, rallied through a Harry Wilson penalty, Sorba Thomas and Brennan Johnson to stun the side ranked eighth in the world.
But De Bruyne rode to his nation's rescue, as he has so often in a stellar career, by steering in Tielemans' perfect cross in the 88th minute.
Defeat was Craig Bellamy's first as Wales manager as they fell just short of a national record of 10 matches unbeaten.