"NASA has decided that Butch and Suni will return with Crew-9 next February, and that Starliner will return uncrewed," NASA administrator Bill Nelson told reporters.
The return of Barry "Butch" Wilmore and Sunita "Suni" Williams has been delayed by thruster malfunctions of the Boeing spacecraft.
The decision marked a fresh public relations headache for Boeing, meaning the two astronauts will have to spend a total of eight months in orbit, not the eight days as originally planned.
After years of Starliner development delays, the spacecraft had finally lifted off in early June carrying veteran astronauts Wilmore and Williams to the ISS.
But while studying problems with the craft's propulsion system, NASA had to put their return on indefinite hold.
Engineers at Boeing and NASA were concerned Starliner might not have the propulsive power to wrest itself out of orbit and begin the descent toward Earth.
NASA officials said Saturday they had opted for the highly unusual option of bringing the astronauts back from the flying laboratory not on their own craft, but aboard a previously scheduled SpaceX vehicle in February.
Under the new plan, the SpaceX Crew-9 mission will take off in late September, but carrying only two passengers instead of the originally planned four.
It will remain moored to the ISS until its scheduled return in February, bringing back its own crew members plus their two stranded colleagues.
The approach represents a further blow to the already tarnished image of US giant Boeing, whose airplane arm has been beset in recent years with concerns about safety and quality control.
Ten years ago, following the retirement of the Space Shuttle, NASA ordered new vessels from both Boeing and SpaceX that could ferry astronauts to and from the ISS.
With two such vehicles available, NASA reasoned, there would always be a backup in case one of the two experienced problems.
But Elon Musk's SpaceX beat Boeing to the punch and has been the lone vehicle used to taxi astronauts for the past four years.
This year's crewed Starliner flight, which followed years of delays and disappointments during the craft's development, was meant to be a last test of the vehicle before it enters regular operations.
NASA has said the astronauts on the ISS have plenty of supplies, are trained for extended stays and have plenty of experiments to conduct.