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SpaceX's Falcon 9 rocket lifted off at 7:03 p.m. ET (2303 GMT) from NASA's Kennedy Space Center in Florida, carrying four astronauts to replace Wilmore and Williams. Both are veteran NASA astronauts and retired U.S. Navy test pilots, and were part of the initial crew that flew Boeing's faulty Starliner capsule to the ISS in June.
The Crew-10 mission, launched while Wilmore and Williams were asleep, will see the new crew arrive at the ISS on Saturday at 11:30 p.m. ET. Wilmore and Williams, along with NASA astronaut Nick Hague and Russian cosmonaut Aleksandr Gorbunov, are scheduled to depart the station on Wednesday as early as 4 a.m. ET (0800 GMT).
The Crew-10 team, who will remain on the ISS for about six months, includes NASA astronauts Anne McClain and Nichole Ayers, Japanese astronaut Takuya Onishi, and Russian cosmonaut Kirill Peskov.