The two killed were identified as Samer Al-Shafiee, 22, who was shot in the neck, chest and belly, and Hamza Kharyoush, 22, who was wounded in the chest, belly, and left leg, the ministry said in a statement.
The two fatalities were taken to a hospital in Tulkarm, it said, adding that another one was injured with minor wounds in the limbs, but he was in stable condition.
The latest victims have thus raised the number of Palestinian martyrs killed by Israeli gunfire since the beginning of this year to 110, including 20 children and two women.