Study finds women have higher genetic depression risk

October 08, 2025 / 10:59 AM

Sharjah24-AFP: In a groundbreaking revelation poised to reshape the landscape of mental health treatment, Australian researchers have unveiled compelling evidence that women are genetically predisposed to a higher risk of clinical depression compared to men. This study, hailed as one of the largest of its kind, meticulously analysed the DNA of nearly 200,000 individuals grappling with depression, uncovering significant genetic markers that may redefine our understanding of this complex disorder.

Key findings: women show more genetic markers

Led by the renowned Berghofer Medical Research Institute, this pioneering study found that women possess nearly twice as many genetic markers linked to depression as their male counterparts. Researcher Jodi Thomas emphasised, "The genetic component to depression is larger in females compared to males." This important discovery not only highlights a long-recognised disparity but also paves the way for more personalised and effective treatment approaches.

Understanding the biological basis

Although it is widely recognised that depression is more common in women, the biological mechanisms behind this had remained unclear—until now. The study found that approximately 13,000 genetic markers linked to depression were identified in women, compared to 7,000 in men. Many of these genetic variations could affect vital biological pathways related to metabolism and hormone production.

Expert insights and implications

Brittany Mitchell, a fellow researcher on the project, expressed optimism about the implications of these findings. "Until now, there hasn't been much consistent research to explain why depression affects females and males differently, including the possible role of genetics," she noted. "As we gain more insights into these genetic disparities, we can begin to tailor treatments that address the specific needs of women."

The study also highlighted potential reasons behind the metabolic symptoms often observed in women with depression, including fluctuations in weight and energy levels. This could reshape how doctors approach treatment, making it more aligned with the unique experiences of women facing depression.

A step toward mental health research

With over 300 million people worldwide affected by clinical depression, as reported by the World Health Organisation, this research becomes more important than ever. It challenges the traditional male-centric focus of mental health studies and advocates for a more inclusive approach that considers gender differences.

Toward personalised treatments for women

As the global discussion on mental health continues to evolve, this essential study represents a significant step towards discovering the genetic secrets of depression, opening the door to treatments that could significantly enhance the lives of many women worldwide.