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Brain organoids reveal how cells age
While typical brain organoids survive for only a few months—offering a limited view of early development—this US-led team pushed the boundaries to study how brains mature over years. Researchers analyzed the ageing tissue using advanced genetic clocks, discovering that the cells continued to change and develop independently. In a unique "time-warping" experiment, mixing older cells with newly grown ones caused the young cells to accelerate their development and rapidly form neurons.
Potential insights into brain disorders
Although these biological "avatars" lack consciousness, sensory input, and personal memories, scientists hope they will unlock vital clues about how disorders like autism and schizophrenia emerge and progress over time. Having fulfilled their purpose in this groundbreaking research, the record-setting organoids have now been destroyed.