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The tragedy involving the bus carrying 30 people happened late Friday in Pernambuco state.
The driver hit some rocks by the side of the road and then got going in the right direction, but crashed into an embankment and the bus flipped over, the statement said.
Eleven women and four men died in the crash. The number of people injured was not immediately disclosed.
The driver emerged with only slight injuries, police said. He was taken to a police station.
Some of the passengers were ejected from the bus, they added.