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Depay converted a ninth-minute penalty and fired home a powerful shot seven minutes later to match Robin van Persie’s record of 50 goals for the Dutch national team. Both achieved the tally in 102 appearances.
Substitute Donyell Malen also scored a double with captain Virgil van Dijk, Xavi Simons, Noa Lang and Micky van de Ven adding the other goals as the Dutch won a second Group G qualifier after beating Finland in Helsinki on Saturday.