The former Manchester United and Real Madrid forward lashed home from close range with his right foot in the 74th minute.
"Great victory and I'm thrilled to announce my 50th goal in 2023," the 38-year-old Portuguese wrote on Instagram after his goal helped Al Nassr reach the semi-finals on Monday in Riyadh.
"All thanks to the unwavering support of my teammates, fans, and my family! There's still room for a few more this year."
The skipper averages nearly a goal a game since joining Al Nassr at the end of last year.
He has also struck 10 times for Portugal in nine matches in 2023.
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