Israeli strikes on Sunday evening killed two Syrian regime soldiers and wounded three others in the central Homs province, Syrian state media reported.
Syrian air defences responded to "hostile targets over the southeastern Homs province", intercepting "several of them", official news agency SANA said.
Citing a military source, it said the strikes hit the regime-controlled Shayrat airbase, inflicting casualties and material damage.
Syrian state television broadcast footage showing air defences intercepting "missiles of an Israeli aggression".
The Britain-based Syrian Observatory for Human Rights reported explosions in the area of the Shayrat airbase, saying four missiles had been fired.
The Israeli army on Sunday declined to comment on the reported strikes.