Arsenal coach Mikel Arteta, back at the Etihad Stadium where he worked as an assistant between 2016 and 2019, watched in horror as his team fell apart early on, with Ilkay Gundogan and Ferran Torres giving City a 2-0 lead inside 12 minutes.
The visitors remained masters of their own chaotic downfall as Granit Xhaka inexplicably got himself sent off for a two-footed lunge in the 35th minute, making an already difficult task that bit more challenging for Arteta's men.
City could then afford to take their foot off the gas but the goals still flowed as British recording signing Jack Grealish set up Gabriel Jesus for City's third just before halftime.
Rodri added a fourth early in the second half, before Torres scored his second late on to complete a miserable afternoon for Arteta and his side.
Another loss means Arsenal are without a point, or even a goal, from their three games so far this season, while City, temporarily at least with rivals in action later in the weekend, are back on top of the standings.
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