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The Gunners showed signs of fatigue following their midweek 3-0 Champions League quarter-final victory over Real Madrid, struggling to break down a well-organised Brentford side in the first half.
Thomas Partey gave Arsenal the lead just after the hour mark, finishing off a move set up by Declan Rice. However, Brentford equalized in the 74th minute when Wissa produced a smart hooked finish.
Arsenal, now second in the table, failed to find a late winner. The draw puts league leaders Liverpool 10 points clear, with a game in hand. Meanwhile, Brentford moved up to 11th place in the standings.