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The Spanish champions took an early lead through French star Kylian Mbappé in the 15th minute. However, their advantage was short-lived as English international Jude Bellingham was sent off after a clear objection just before halftime (39th minute).
Osasuna equalised in the 58th minute through a penalty from Croatian Ante Budimir. This match marked Real Madrid's third consecutive game without a win, following a draw against Atletico Madrid (1-1) and a loss to Espanyol (0-1) in previous rounds.
Despite the draw, Real Madrid remain at the top of the table with 51 points, two ahead of Atletico Madrid, who have a chance to take the lead if they defeat Celta Vigo later. Barcelona, who play Rayo Vallecano on Monday, sit three points behind the leaders.