The events of October 17, 1961 were covered up for decades and the final death toll remains unclear. But many historians believe it could amount to several hundred.
The rally was called in the final year of France's increasingly violent attempt to retain Algeria as a north African colony, and in the middle of a bombing campaign targeting mainland France by pro-independence militants.
On Saturday, one day ahead of the formal anniversary, Macron will take part in a memorial ceremony for the victims at a park on the Paris outskirts from 1330 GMT.
A major question is whether he issues a formal apology for the actions of the Paris police that day or expresses regret, as the president seeks to carve out a modern relationship with France's past.
The Paris police chief at the time, Maurice Papon, was later found to have collaborated with the Nazis during World War II.
The Elysee said the ceremony would take place in the presence of relatives of the victims, civil society activists who have campaigned for recognition of the massacre and veterans for Algeria's struggle for independence.
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