The module, a multipurpose laboratory named after the Russian word for 'science', is due to dock with the ISS at 1326 GMT, Russia's space agency Roscosmos has said.
Roscosmos head Dmitry Rogozin last month suggested Moscow would withdraw from the ISS in 2025 unless Washington lifted sanctions on the space sector that were hampering Russian satellite launches.
Launched in 1998, the ISS is a multinational project and comprises two segments, a Russian one and another one used by the United States and other space agencies.
"After its commissioning, the Russian segment will receive additional room for arranging workplaces, storing cargo and housing water and oxygen regeneration equipment," Roscosmos said in a statement on Wednesday.
It said the module performed its final corrective maneuver on Wednesday with no new orbit connections planned before docking.
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