The European planemaker said on Wednesday the new line, to be installed in the deserted assembly hall where it once built the now-abandoned A380 superjumbo, would open by end-2022.
Airbus decided in 2019 to halt output of the world's largest jetliner and the last A380 rolled out in March, leaving the world's second-largest industrial building in limbo, according to Reuters.
Airbus plans to use at least part of the Jean-Luc Lagardere building to add a new line with state-of-the art facilities to meet demand for the smaller A321neo, which has seen a rise in demand to represent more than half of its single-aisle backlog.
That will replace one of the original lines used for the A320, a slightly smaller and earlier model, in Toulouse.
Airbus suspended similar plans in April last year when the global outbreak of COVID-19 forced it to cut global production.
The new move comes as Airbus tells suppliers to be ready for a further recovery in single-aisle output to 53 jets a month by end-2022, first reported by Reuters on Tuesday.